Hydrogen atoms can bind to carbon atoms {acetylation}.
Amino acids can bind to carboxylic-acid groups {amino acid conjugation}, on anti-inflammatory, hypolipidaemic, diuretic, and analgesic drugs.
Enzymes can change drugs to make them toxic {bioactivation}.
Drug metabolism has oxidations and reductions {biotransformation}.
Two charges can exchange {charge-transfer coupling} in reactions.
Molecules can attach small molecule {conjugation, molecule}.
Processes can make rings {cyclization}.
Glucuronic acid allows glucuronide formation {glucuronic acid conjugation}.
Molecules can conjugate with glutathione {glutathione conjugation} to form mercapturic acid.
Atoms {hydrogen bond acceptor} (HBA) can add hydrogen atom.
Atoms {hydrogen bond donor} (HBD) can release hydrogen atom.
Hydrogen atoms can abstract {hydrogen transfer}.
Hydrogen atoms can bind to oxygen atom {hydroxylation}.
Enzymes can change conformation to allow substrate binding {induced fit}.
Drugs can form complexes with receptors and then cause chemical or conformational changes {intrinsic activity, drug}.
Drug metabolism has oxidation or reduction {Phase I enzyme reaction}.
Drug metabolism has conjugation with small molecules {Phase II enzyme reaction}.
Hydrogen atoms removed from molecules {proton abstraction} can make water.
After ATP activates sulfate, sulfotransferase makes sulfate esters {sulfate conjugation}.
5-Chemistry-Biochemistry-Drug-Metabolism
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Date Modified: 2022.0225